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0.5 mg/0.1 ml saline/each eye) in rats immediately produced moderate generalized irregularity in the diameter of blood vessels with moderate atrophy of the optic disc and faint presentation of the choroidal blood vessels, and these lesions rapidly progressed to the severe stage

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0.25 mg escalating toward 2.4 mg by ~week 17) Plasma half-life Approximately 7-8 days (reported ~159-195 hours) Regulatory status Investigational